Profile
Professor of Pharmaceutical
Chemistry, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King
Abdulaziz University, Jeddah, Saudi Arabia.
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Lipidopmic and Biomarkers using LC-MS/MS
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Analytical method development and validation. Setup of the analytical methods including validation procedures, execution of analytical protocols, management of the work load and work flow, and setup of good laboratory practice. Stability indicating assay method development,
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Trans-esterification of esterified fatty acids
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Analysis of total phenolic/organic acids in herbal products
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Analysis of petroleum residue in sea water
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Handling of plasma/blood samples for analysis of targeted analytes
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Impurity testing and photostability testing of drug substances and products, compatibility study of drug substance with the combined excipients, analytical methodologies including high-performance liquid chromatography (HPLC), LC-MSMS (Ion-Trap), MRM mode, thin-layer chromatography (TLC), Gas chromatography, GC-MS.
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Installation and operational qualification of analytical instrument, and Management of Quality Control Department.
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Documentation system in quality control lab including Standard Operating Procedures; writing standard operating procedure, assessment of the results, handling and issuing of the generated records, maintenance and calibration of the laboratory instrument, materials inventory, training of QC personnel, assistance personnel and candidate students, drafting of progress reports
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Strategy of drug development and qualification, and Compiling and processing of registration files for MCA/EMEA – EU application.
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Drug metabolism and stereoselective drug metabolism study, Derivatization for HPLC-UV detection, Conducting the analytical part of bioequivalence testing according to USP/FDA/ICH/EMEA guidelines, Implementation and learning of regulatory guidelines including; current Good Manufacturing Practice (cGMP), Good Laboratory Practice (GLP), International Conference of Harmonization (ICH), Food and Drug Administration (FDA), and official Compendia monographs.
Skilled on the following techniques / Instrumentation
High-performance liquid chromatography coupled with diode array detector – mass spectrometer.
Tandem mass spectrometry for trace analysis and characterization of chemical molecules
Gas chromatography – quadrupole – electron impact
Solid phase extraction using C8-18, C-SiOH, or Extrelut® columns
Education
- 1994
Doctorate degree from Pharmaceutical ChemistryPharmacy, Bonn/Assiut University, أسيوط, مصــــــــر
- 1994
Doctorate degree from Pharmaceutical ChemistryFaculty of Pharmacy, Bonn / Assiut, بون, المــانــيا
- 1994
Doctorate degree from Pharm ChemPharmacy, BONN, بون, المــانــيا
Employment
- 1984-حاليا
Professor, Assiut University, Assiut, مصــــــــر
- 1996-1998
Post-doctor fellow, Cincinnati - OH university, Cincinnati, امــريــكـا
- 1999-2001
R&D and QC Manager, T3A Pharmaceutical, أسيوط, مصــــــــر
- 2003-حاليا
Professor, King Abdulaziz University - Faculty of Pharmacy, جدة, المملكة العربية السعودية
Research Interests
-
Lipidopmic and Biomarkers using LC-MS/MS
-
Analytical method development and validation. Setup of the analytical methods including validation procedures, execution of analytical protocols, management of the work load and work flow, and setup of good laboratory practice. Stability indicating assay method development,
-
Impurity testing and photostability testing of drug substances and products, compatibility study of drug substance with the combined excepients, analytical methodologies including high-performance liquid chromatography (HPLC), LC-MSMS (Ion-Trap), MRM mode, thin-layer chromatography (TLC), Gas chromatography, GC-MS.
-
Installation and operational qualification of analytical instrument, and Management of Quality Control Department.
-
Documentation system in quality control lab including Standard Operating Procedures; writing standard operating procedure, assessment of the results, handling and issuing of the generated records, maintenance and calibration of the laboratory instrument, materials inventory, training of QC personnel, assistance personnel and candidate students, drafting of progress reports
-
Strategy of drug development and qualification, and Compiling and processing of registration files for MCA/EMEA – EU application.
-
Drug metabolism and stereoselective drug metabolism study, Derivatization for HPLC-UV detection, Conducting the analytical part of bioequivalence testing according to USP/FDA/ICH/EMEA guidelines, Implementation and learning of regulatory guidelines including; current Good Manufacturing Practice (cGMP), Good Laboratory Practice (GLP), International Conference of Harmonization (ICH), Food and Drug Administration (FDA), and official Compendia monographs.
Scientific interests
Explore the carcenogenics in food and medicinal stuffs
Exploring the anticancer entities in camel urine/milk
Profiling of biomarkers for early diagnosis
Courses
| Pharmaceutical Chemistry PC 201 |
201 |
PC |
| Quality Control |
421 |
PC |
| Advanced Instrumental analysis of Pharmaceutical compounds |
800 |
PC |
Areas of expertise
| Pharmaceutical Analytical Chemistry |
Development and application of chromatographic methods for sensitive monitoring or discovery of substances in biological samples |
| Pharmaceutical industrial area |
Establishement of Pharmaceutical industry, Licincing, quality control, regulatory affair, research and development activities according to GMP/GLP/ICH/FDA guidelines |
| Professor of Pharmaceutical Chemistry |
Pharmaceutical Analytical Chemistry |